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KMID : 1123920140280030296
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 3 p.296 ~ p.302
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Inhibitory Effects of Saposhnikoviae Radix Extracts on the Melanin Production and Elastase Activity in B16F10 cells
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Choi Chan-Hun
Wang Kung-The
Cho Hye-Rin
Jeong Jong-Kil
Jung Hyun-Woo
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Abstract
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Saposhmikoviae Radix can treat various skin disease by anti-pruitus and anti-inflammatory effects. This study was designed to investigate effects of Saposhmikoviae Radix Extracts(SRE) on skin elasticity and whitening using B16F10 cell lines. In this experiment, We observed effect of SRE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. In results, SRE treated group showed lowered proliferation rates significantly compared to non-treated group. More than SRE 125 ㎍/㎖ of treated groups were lower levels of melanin synthesis respectively. SRE did not show inhibitory effect on tyrosinase activities in vitro and in B16F10 cells. Finally, SRE suppressed elastse type Ⅰ and Ⅳ activities in dose-dependent manner in vitro. And SRE also slightly suppressed elastase activities in B16F10 cells. In conclusion, these results suggest that SRE can inhibit melanin synthesis and inhibt elastase activity. So, We suggest that SRE can be maintained skin elasticity or whitening.
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KEYWORD
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Saposhmikoviae Radix, melanin, skin elasticity, skin whitening, B16F10 cell lines
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